This is from the future I always dreamed about, amazing
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The lab did specify that there's a looooong road between here and putting this in the clinic, but it's a good to see.
God that was such a bad intro tune. Adding the acoustic guitar didn't help. Loved the show until they went full "Timecop".
Never go full Timecop.
The intro sequence completely slapped though. A Wright Model A taking off, Glamorous Glennis rolling away, OV-101 Enterprise being pushed out of the hangar, the Spirit of St. Louis taxiing out, Saturn V's launching, LM Eagle's gear check, Actual footage of Sojourner rover rolling up to sample a Martian rock making this the first sci-fi show to feature footage actually filmed on another planet, Bruce McCandless' untethered spacewalk from Discovery, the International Space Station taking shape...it's a shame an intro that fucks that hard was wasted on Bakula's Enterprise.
"We've built a new kind of apparatus and we are going to god damn mother fucking learn something even if it kills us in a new and exotic way."
I genuinely wonder where the line is between curing defects and eugenics. It seems razor thin how it can swing easiy into dark territory.
Isn't eugenics more about choosing who can reproduce for the best outcome? Curing after the facts doesn't seem to fit that.
I think what is talking about is like everyone now forced to have blue eyes with gene editing so is it considered a type of soft genocide or something.
Nah, man, forget blue eyes. Think neon purple. With natural blue hair. Fucking anime shit.
And just imagine what furries will do to themselves once they get their paws on this tech...
I remember this was literally the question posed to us by an ethics professor 20 years ago. Now it's a reality.
A person with Down's can live a happy fulfilling life, but most parents would never choose to have a child with Down's if it could be born 'normal' instead. So we're essentially removing them from the gene pool and human race.
It's eugenics for sure. I'm not sure if it's unethical though. It's pretty complex.
we're essentially removing them from the gene pool
I don't think Downs works like that.
It's already being removed, since people choose abortion over downs and since people with Downs don't have children (normally).
It is not hereditary. It's an error or mutation that can occur for anyone. The chances are higher the older the parents are.
This isn't eugenics or close to it, it's fixing actual problems before someone is born, not choosing who has rights to breed. If they announced a therapy to guarantee a child will grow up immune to corporate propaganda or be able to use their brain in a rational, well-planned and thoughtful way, and have exceptional language skills, we should voluntarily hand the world over to them. Because what's happening right now is the opposite of that.
Right now capitalism is imposing eugenics on us. The system and the cost of life has created a very real system deciding who can have families. If tools emerged that could guarantee the kids we DO have aren't subject to the same weaknesses and limitations, we need to capitalize on every advantage we can.
I did not realize CRISPR was so powerful as to remove chromosomes entirely. Can CRISPR be used to change someone's genetic sex? Republicans would freak out.
RED ALERT! WOKE LIBERAL COMMUNISTS ARE USING CRISPR BEAMS FROM LOW IRBITING SATTELITES TO FORCIBLY CHANGE OUR GENDERS! BUY MY ANTI-WOKE SUPPLIMENTS TO PROTECT YOUR MANLINESS.
By my limited understanding that might be feasible right now in utero, which obviously is not exactly what we want.
I think that maybe in the future we could change someone's sex when they're older. Honestly I think it's maybe just the matter of research on this not being focused on genetic changes after the womb.
While this is fabulous news I do worry that there could be similar done for other genetic conditions that are far more contentious as to whether they're a disability not.
Neurodivergence is the one that springs to mind right away. The majority of people on the autism spectrum are at level 1. While it has negatives there are positives into thinking and seeing the world differently.
How many of those would have been 'curered' in the womb by scared parents who've just been told that their child will be born autistic? Scared parents who's fear will mean when hearing that they think of someone at the far end of level 3.
Then what about for ADHD and dyslexia.
What about other physical conditions like dwarfism etc.
Pretty sure Autism is a lot more complex genetically and we don't even know just how complex.
So...Remember the X-Men series of movies? I forget which of the films it was, I stopped giving a shit about superhero movies a decade before it was cool, but one of them involved a "mutant cure." Most of Professor X's mutants saw it as an existential threat, but Rogue--whose 'powers' utterly sucked--saw it as something she wanted to do.
Ultimately I think the key here is individual consent. Yes and No need to be equally valid answers otherwise it gets pretty fucked up.
Some folks make a pretty good living for themselves looking at the world slightly differently than everyone else, other folks would like to do something with their life other than drool. Surely we the civilization that can split the atom and splice the genome can help both of these people live their best lives? Otherwise what the fuck are we even doing here?
I don't know if you personally have any disabilities, but generally, when I see this take, the person doesn't.
I'd take a crispr treatment without hesitation. And everyone I know would do the same. My partner and I are doing IVF not for fertility reasons but to ensure certain genes don't get passed down to our kids.
That whole disability-is-a-positive view is a very privileged thing to say.
Yeah, on the one hand it isn't fair to let someone be born with a condition that negatively effects their life when there's a treatment to prevent it happening. On the other hand, as you say it's good to have divergent people in society - there really is strength in diversity.
This is the beginning of countless sci-fi stories. According to the TV and movies I've seen, this will lead to customizing fetuses, mostly for intelligence, and then the question becomes does society accept those people as their leaders (Brave New World) or criminalize their gene-enhanced intellect (Star Trek: Deep Space Nine)?
As I recall, the reason the Federation outlawed genetic manipulation is due to what happened with the Eugenics Wars, the details of which are murky due to temporal interference, but one of the root causes was clear. While the end results of genetic engineering (Khan Noonien-Singh and his Augments) were undoubtedly superior to normal humans in every way, they also incredibly aggressive and arrogant, a flaw their creators could not correct, as the science was still in its infancy. One of the scientists remarked that "Superior ability breeds superior ambition".
Being raised in labs by dickheads may have also been a contributing factor in their personality flaws.
Can it remove my depression and make me love myself?
Holy crap. The obvious use for this would be in vitro. However, I cannot wait to see how this affects those already born. Could it be used on someone who is a 7 year old to rid them of this? What if they're 50? So cool. Can't wait to see where this goes.
And in the US, religious assholes want to ban IVF for exactly this reason, because it's "playing God".
Until someone who knows more tells me otherwise, no. It would have to be applied to a human at the stage of a single cell
You are right (at the 8 cell stage you can still separate them and treat them one at a time, giving you multiple shots at IVF)
Two of the main issues regarding gene editing when not talking single cells are the transfer into the nucleus, and then accessing the DNA you want.
In bacteria, the DNA kinda just swims around in the cell, which makes editing easy if you can get the CRISPR/Cas9 complex in the cell. But animal cells have another membrane surrounding the DNA, making the transfer less than straightforward.
Regarding access: our DNA isn't lying around like mom's spaghetti, but rather pretty tightly packed around histones - a protein octamer.
This means that your target might not be reachable (the cell itself has 3 options iirc: slide the DNA over the surface of the histone, replace a part of the histone with an alternative, or remove the histone altogether) Since the way the DNA is wound around the histones affects gene activity (something tightly packed is not active, something in a loose area is getting transcribed into mRNA and therefore possibly active), you cannot just unwind all of it.
The only time this is not the case is during cell division, where the nucleus is getting dismantled so the DNA can be duplicated and both new cells can get their own copy. But many cells do not divide in an adult (except for a reservoir of stem cells which are there to replace lost cells)
So, it's all very complicated.
"Gattaca" and "Brave new world" are becoming reality.
CRISPR is the uranium of biology. Could use it to make cheap, reliable, clean energy, or could use it to make nukes.
That's a dilemma. The kids and parents not having the challenges is great, but also people with Downs are often some of the best humans to exist.
I work with special needs adults. Your experiences, while valid, with many of those that arent so disabled that they actually can engage with society, do not represent those with more extreme versions of this disability.
Often they will never get to experience the fullness of life they could without. Basically, people with Downs who dont have caretakers with means are fucked pretty hard.
Of the 6 I interact with daily, I think they all would rather not have the disability, and 2 have said they would trade places with the guy in the wheel chair that has seizures sometimes, but is otherwise living a normal life.
It's fine and not at all contradictory to care for existing people with Downs and also work to eliminate the condition.
Idk man, having down syndrome also gives you a much greater chance of things like heart defects. Life expectancy has improved recently to 50-60yrs old for them according to a quick search. I don't think there's a dilemma here at all. I wouldn't want a disease that decreases my lifespan.