this post was submitted on 21 Jan 2025
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Science

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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[–] Gullible@sh.itjust.works 60 points 1 month ago (1 children)

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[–] nooneescapesthelaw@mander.xyz 7 points 1 month ago (1 children)

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn't know?

[–] scarabic@lemmy.world 7 points 1 month ago (1 children)

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

[–] nomy@lemmy.zip 3 points 1 month ago

Like a lil cashew down there.

[–] RobotToaster@mander.xyz 42 points 1 month ago (1 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] __nobodynowhere@lemm.ee 7 points 1 month ago (2 children)
[–] rickyrigatoni@lemm.ee 28 points 1 month ago

The hat man cleans your brain for you.

[–] RobotToaster@mander.xyz 8 points 1 month ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[–] flicker@lemmy.dbzer0.com 27 points 1 month ago (2 children)

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[–] pelespirit@sh.itjust.works 9 points 1 month ago

Be careful about assuming that your drugs are what they're talking about. Yours sound like they're balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

[–] ChadMcTruth@lemmy.world -2 points 1 month ago

you probably just need fresh nutrients

[–] anarchrist@lemmy.dbzer0.com 15 points 1 month ago (1 children)

I wonder if ketamine has the same effect, he asked apropos of nothing...

[–] metaStatic@kbin.earth 12 points 1 month ago (1 children)
[–] MossyFeathers@pawb.social 12 points 1 month ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[–] workerONE@lemmy.world 11 points 1 month ago (3 children)
[–] Agent641@lemmy.world 6 points 1 month ago (1 children)
[–] rosa666parks@lemmy.dbzer0.com 2 points 1 month ago (1 children)

Then gets you really sleepy

[–] sunzu2@thebrainbin.org -1 points 1 month ago

Being knocked out is not sleep.

[–] TypicalHog@lemm.ee 3 points 1 month ago

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

[–] sunzu2@thebrainbin.org 0 points 1 month ago (1 children)

Se thing as any other substance

Weed too

[–] workerONE@lemmy.world 1 points 1 month ago (1 children)
[–] sunzu2@thebrainbin.org 0 points 1 month ago

That shit don't last long enough?

[–] sunzu2@thebrainbin.org 9 points 1 month ago (1 children)

Alcohol and weed does the same thing, just because you are out. Doesn't mean you are sleeping.

Good to see this common sense being confirmed

[–] otp@sh.itjust.works 1 points 1 month ago

I wouldn't even call it common sense. I remember being taught like 20 years ago that we don't even know for sure why we need to sleep (aside from the fact that we get tired and sleep is pretty good at helping with that).

[–] peoplebeproblems@midwest.social 7 points 1 month ago (2 children)
[–] RvTV95XBeo@sh.itjust.works 7 points 1 month ago

That usually helps me sleep better too

[–] scarabic@lemmy.world 0 points 1 month ago
[–] some_guy@lemmy.sdf.org 6 points 1 month ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[–] TacoButtPlug@sh.itjust.works 5 points 1 month ago (2 children)

I wonder what melatonin does

[–] Agent641@lemmy.world 5 points 1 month ago (2 children)

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[–] SirQuackTheDuck@lemmy.world 9 points 1 month ago

Probably just stick to the side of your head.

Have you tried eating the cheese instead?

[–] TacoButtPlug@sh.itjust.works 4 points 1 month ago (1 children)

Charlie Kelly... who taught you about Lemmy?

[–] DaCrazyJamez@sh.itjust.works 2 points 1 month ago

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain...

[–] TypicalHog@lemm.ee 5 points 1 month ago (1 children)

It's a natural hormone brain produces that signals to the body that it's zzz time.

[–] TacoButtPlug@sh.itjust.works 2 points 1 month ago (1 children)

I love it for bedtime and it helps my autoimmune shit. Glad it's not brain bad.

[–] otp@sh.itjust.works 2 points 1 month ago

Aside from possibly becoming a dependency, I'd imagine it doesn't interfere with sleep quality. It's what builds up in your body to make you sleepy/fall asleep.

Too much might keep you groggy in the morning though.

[–] intensely_human@lemm.ee 5 points 1 month ago

If you want your brain to clean out waste at night, you need to be taking sweeping pills.

[–] Hackworth@lemmy.world 4 points 1 month ago* (last edited 1 month ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[–] Cephalotrocity@biglemmowski.win 2 points 1 month ago (1 children)

Apparently the water supply in my town is dosed with sleeping pills.

[–] pelespirit@sh.itjust.works 9 points 1 month ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater