this post was submitted on 30 Jun 2025
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I had a colleague tell me that GLP-1s inhibit individual fat cell (adipocyte) growth, but can ultimately lead to adipocyte proliferation, especially if lifestyle modifications aren't made, and that this is a major factor in rebound weight gain. Can't speak to the veracity myself and am having trouble interpreting the literature off-hand.
This sort of detail is well beyond my level of expertise. All I know is that at this point they appear to work about as well as anything else and be a lot more comfortable that hardcore calorie counting and denial for a lot of people, with usually tolerable side effects. Some evidence suggests long term success and some suggests that they're just like everything else. As far as I know there is no data yet on whether it is safe to spend a lifetime going on and off them as one would expect to end up doing with any diet regime; which would be relevant if they have about average long term results.
Below Lydmila linked a combo therapy which seems to have interesting results, so that's exciting.