this post was submitted on 05 Aug 2025
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Although I've never thought much about it I would think that neuropeptides that are produced in the brain would likely have local activity. Orexin is an endogenous neuropeptide that can be administered in an inhaled form with a very potent effect. I listened to a talk on it once and apparently you can be going on 20+ hours awake and barely able to keep your eyes open to immediately awake like you slept for 12 hours. He said that the air force uses it for B-2 pilots and other extremely long range missions.