this post was submitted on 30 Jun 2025
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These drugs modify the hormonal signals associated with hunger, side effects can include gastrointestinal upset including nausea but they don't work by making you nauseous no.
There's a lot of fucking terrible social stigma around fatness and losing weight through "improper" methods. Frankly I think people should fuck right off of telling other people what they should or should not do with their bodies.
These drugs appear to be relatively well tolerated, better than other effective weight loss drugs. Side effects appear manageable but that is in the context of other weight loss drugs that work being stuff like meth so... you know. Some people have great experiences, some don't. For people it works for they typically just describe not being hungry.
You should know that so far basically nobody knows how to reliably lose weight and keep it off at a population level. Evidence is emerging that these drugs may be no different. What I mean is that whatever causes someone to feel like the amount they eat is the right amount seems to be frustratingly persistent, and after interventions people often drift back towards wherever they were at prior. That said, each person is individual and what works for you might not work for others. Also if you'd feel better about yourself if you lost some weight and slowly regained it over the years then that's meaningful positive impact for you.
You should talk to a doctor, and discuss options. It's possible a combined approach or some other intervention would be more appropriate, you also need to know the state of your body before deciding if any particular thing would be safe and effective. Like are your organs healthy and whatever. If you want a bit of a dive into the meds from a critical but non judgemental angle: https://podcasts.apple.com/au/podcast/ozempic/id1535408667?i=1000630805156 is pretty thorough and goes over the good, the bad, and the bullshit.
At a population level? Affordable healthy food, promoting an active lifestyle, and reduced stress...this stuff isn't a mystery. Weight gain in the average person isn't due to 'overeating' (ED or otherwise) it is due to sedentary lifestyle and the easy accessibility of nutrient poor, calorie dense, cheap food.
Some individuals find success with long term weight loss but there is no known approach that can be applied to a population that yields reliable results.
We can imagine many things that theoretically work but either compliance is low at the study recruit level (they don't work) or they are no practical in our current sociopolitical climate (they don't work).
The reality is we don't know what to do, we have ideas but we can't do experimental societal transformations to do the studies.
To my knowledge there is no good scientific evidence of what you propose, if you have it then by all means please share it.
Calorie deficit. Burn more calories by avoiding sedentary lifestyles and reduce excess calorie intake (soda, high fat foods, calorie dense meals)
Ah that is a common misconception of an oversimplified model. In general long term compliance is low, it's hard to feel hungry all the time. If people increase calories to a normal level after restricting for loss they typically still feel hungry, and will intuitively eat until they have regained most of the weight they lost.
Feeling hungry for the rest of your life blows hard and compliance isn't there so therefore it doesn't work.
People with bodies that are working well typically don't feel hungry after overeating. I know if I eat cake for breakfast I just wont feel hungry at lunch, whereas some people will continue to feel hungry even if they fill up on "healthy" food. While it's true that some foods are more satiating than others it isn't true that if one eats only highly satiating food and avoids "junk" foods their bodies will self regulate well.
Exercise is not actually very effective for weight loss, it tends to make people hungrier than the calories it burns. If I run 10kms I burn like half a meal's worth of calories but I sure as hell feel like eating a double helping of brunch afterwards. While there are many compelling reasons to avoid a sedentary lifestyle it isn't true that we can finger sedentary lifestyles for fatness.