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Nearly half of depression diagnoses could be considered treatment-resistant.
(www.birmingham.ac.uk)
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I am quite familiar. I have desired the sweet embrace of death since I was 6. Literally all of my life that I remember. I said deeply sad because it's more succinct than all that you said. My point is that, that feeling of hopelessness and exhaustion IS A REASONABLE RESPONSE to the world we live in. Or rather, an understandable biological response. It's not something that should be medicated away, we should change society to avoid that for more people.