jet

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[–] jet@hackertalks.com 1 points 14 hours ago* (last edited 13 hours ago)

Notes:

Monitoring of adherence should be performed by quantitative, unbiased biomarkers, such as the glucose-ketone index (GKI)

In particular, recent advancements in our understanding of cancer metabolism have led to renewed interest in Warburg’s theory of carcinogenesis (7–9). According to this theory, malignant cells are characterized by distinct structural and functional mitochondrial abnormalities, leading to compensatory metabolic dependencies

Unlike normal brain cells, that have evolved to metabolize ketone bodies for energy when glucose availability is low, GBM cells depend on glycolysis for growth and are unable to efficiently metabolize ketones due to impaired mitochondrial function

^^This sentence has a assumption, incorrect, that the brain preferences glucose. I think this is reversed, in the absence of ketones the brain can use glucose. In people with both ketones and elevated glucose levels in the blood a healthy brain burns ketones at a 70:30 preference.

3.3 Patient 3

After 6 months the patient decided to abandon the diet due to perceived dietary restrictiveness. On April 2022, 4 months after KD discontinuation, GBM recurrence

This is super interesting, she recovers, quits keto, the GBM comes back, and gets back into keto and has a ECOG of 0.

Of the 12 patients who did not adhere to the diet, only one reached 36 months of survival, while the rest have died in an average time of 15.7 ± 6.7 months, with a 3-year survival rate of 8.3%

This applied to three of our patients who had already undergone surgical resection, radiation, and chemotherapy. They felt reassured that they had done everything possible and saw no need to adhere to a demanding diet. Another reason was a lack of trust in the diet; four of our patients did not believe that, following conventional therapies, a simple diet could be beneficial, despite initially agreeing to follow it. Older patients, in particular, struggled to adjust their eating habits and discontinued the diet shortly after starting. Additionally, two patients stopped the diet due to the absence of a supportive environment, while another two discontinued it due to financial constraints, as they found the ketogenic diet to be relatively costly to implement

^^This is just sad

Tumor recurrence despite diet adherence can be explained by secondary metabolic dependencies of tumor cells (58–61). It is important to acknowledge that dietary strategies alone, such as ketogenic diets or fasting, cannot fully deplete glucose from the tumor microenvironment.

The liver makes glucose, steroids increase glucose levels, etc


Thoughts

This was a dietary ketogenic intervention, I wonder how the outcomes would differ with exogenous ketones? Since compliance with the intervention was so low (33%), could we have seen the other 66% benefit from a ketogenic diet + exogenous ketones? The one patient in the study (patient 5) who took exogenous ketones did suffer a relapse, i would have liked to see their GKI history.

Several of the patients reported constipation when starting the keto diet, probably because they increased fiber consumption. It would be interesting to see the same intervention without fiber. We have other papers indicating full resolution of constipation with the removal of fiber.

The theme amongst the patients is that the lower the GKI, and the better adherence, the better the outcomes and fewer recurrences.

 

Extremely promising results of the application of a strict ketogenic diet to glioblastoma survival rates.

Among the 18 patients participating in the study, 6 adhered to the ketogenic diet for more than 6 months. Of these patients, one patient passed away 43 months after diagnosis, achieving a survival of 3 years; another passed away at 36 months, narrowly missing the 3-year survival mark; and one is still alive at 33 months post-diagnosis but has yet to reach the 3-year milestone and is, therefore, not included in the final survival rate calculation. The remaining 3 are also still alive, completing 84,43 and 44 months of life, respectively. Consequently, the survival rate among these patients is 4 out of 6, or 66.7%. Of the 12 patients who did not adhere to the diet, only one reached 36 months of survival, while the rest have died in an average time of 15.7 ± 6.7 months, with a 3-year survival rate of 8.3%. Comparing the survival rates of the two groups, we see that the difference is 58.3% (66.7% versus 8.3%) and is statistically significant with p < 0.05 (0.0114) and X2 = 6.409.

Full Paper https://doi.org/10.3389/fnut.2024.1489812

[–] jet@hackertalks.com 2 points 23 hours ago

Yes, exactly this

[–] jet@hackertalks.com 9 points 1 day ago

If someone has already said what I was going to say, I upvote and don't comment.

[–] jet@hackertalks.com 3 points 1 day ago (1 children)

Sittwe residents are prevented from leaving the city by both road and water by the regime, which has been preparing defensive bunkers in over 20 villages around Sittwe since last year.

They are using the people as human shields...

[–] jet@hackertalks.com 4 points 1 day ago

In Malaysia it's about $300/month for a live in maid (plus food).

[–] jet@hackertalks.com 6 points 1 day ago* (last edited 1 day ago) (1 children)

https://grapheneos.org/usage#sandboxed-google-play-configuration

If your having unsatisfying location, go through this guide to turn on Google everything for location.

You will need to grant "Allow all the time" Location access to Google Play services along with the Nearby Devices permission for it to have all the access it needs. You need to use the "Google Location Accuracy" link from the sandboxed Google Play configuration menu to access the Google Play services menu for opting into their network location service, otherwise this is all pointless

[–] jet@hackertalks.com 23 points 2 days ago

A man with one clock knows what time it is with certainty. A man with two clocks is never sure

[–] jet@hackertalks.com 1 points 2 days ago

Suddenly I feel compelled to build a flight sim rig

 

The state of nutritional ketosis is not only safe but may be optimal in pregnancy. Women with 'morning sickness' have better pregnancy and health outcomes for their babies than the 'norm' and significantly better than those women affected by diabetes through the pregnancy.

  • 1:10 Proving the Safety of Intervention
  • 2:06 Pregnancy/Newborn/Infant - Ketosis
  • 4:54 Pregnancy Keto vs Diabetes - Safety
  • 6:54 Proving the Safety of #Keto
  • 7:17 Conclusions - Safety of #Keto
  • 8:24 References
[–] jet@hackertalks.com 10 points 2 days ago (3 children)

One compelling theory I've seen for why children learn languages so absolutely quickly, is there in a completely positive environment, where every single person around them encourages them to learn, and any mistakes are seen as cute and meet with more encouraging. There is no shame in a child's language acquisition.

Adults... Have more roadblocks :)

Glad your getting out there!

[–] jet@hackertalks.com 1 points 2 days ago

Sure. Anyway, I'm not a fan of alcohol, but it has enough bad things we can prove it does, no reason to use weaker evidence to try to make it more dangerous

 

Dave Aspray is a little out there, but this is absolutely delightful interview focusing on Ben Bikman and his research. The energy and excitement they share during this interview is infectious.

I would say this is a good interview for someone to get started and see a high level tour of the ketogenic landscape.

If you’ve been told calories in, calories out is the key to preventing weight gain, think again. The truth is, blood sugar levels, insulin sensitivity, and mitochondrial performance play a far greater role in how your body stores and burns fat. You’ll learn how intermittent fasting, keto diets, fat fasting, and protein fasting can fix your blood sugar, optimize metabolic function, and even contribute to Alzheimer’s prevention. Dr. Bikman also reveals why ketones outperform glucose for brain function, how nasal insulin spray acts as a cognitive enhancer, and the shocking impact of environmental toxins on metabolic dysfunction. Plus, why some people can eat 400 grams of carbs and never gain fat—and what that means for your own metabolism. What You’ll Learn: • How to fix your blood sugar and reverse insulin resistance for lasting energy and health • The real science behind ketones in brain function and why ketones outperform glucose • Why fat fasting can help prevent weight gain and improve metabolic health • The hidden impact of environmental toxins on metabolic dysfunction and diabetes • How nasal insulin spray enhances cognition and its link to Alzheimer’s prevention • The role of intermittent fasting, keto diets, and metabolic flexibility in longevity • The truth about calories in, calories out—and why hormones control your metabolism This episode will challenge everything you’ve been told about food, fat storage, and longevity—and give you the tools to take control of your health today.

 

Surviving in a World That FEARS The Carnivore Diet Are you tired of explaining your diet every time you sit down for a meal? Do you feel like an alien in a world full of bread baskets and carb-loaded sides? 🤯 In this video, I’m breaking down 10 essential tips to help you navigate restaurants, social gatherings, and awkward conversations without feeling like the odd one out.

From handling the fiber police to ordering at restaurants like a pro, you’ll walk away with practical, real-world advice to stay confident and stress-free as a carnivore. Whether you’re new to this lifestyle or a seasoned steak-eater, these tips will make your life way easier.

  • Why eating in public as a carnivore can be awkward
  • Tip #1 – The power of “No, thank you” (Keep it simple!)
  • Tip #2 – The whole foods strategy (How to phrase your diet)
  • Tip #3 – The fiber myth (How to shut down the poop question)
  • Tip #4 – How to navigate social gatherings like a pro
  • Tip #5 – The importance of finding your tribe (You’re not alone!)
  • Tip #6 – Using humor to handle diet critics
  • Tip #7 – Eating out stress-free (Master the restaurant game)
  • Tip #8 – The perfect one-liner for nosy people
  • Tip #9 – How to stay prepared when traveling or working long hours
  • Tip #10 – The truth: You don’t owe anyone an explanation
3
submitted 6 days ago* (last edited 6 days ago) by jet@hackertalks.com to c/carnivore@lemm.ee
 

Not pure carnivore: Carnivore + coffee/tea + pistachios + 100% dark chocolate

Weight Change: -19kg

diet

With few exceptions, this was my daily meal.

Micronutrient results

I'm surprised the vitamin A is so low, I eat 30g of beef liver every day.

The ferritin being so high is concerning, it might be a immune response to a bad respiratory infection I was developing (blood draw was done right before 3 days of agonizing coughing).

Metabolic Metrics

  • Blood Pressure 118/77
  • Resting Heart Rate 60
  • Fasting Insulin: 12.40 uU/mL
  • Fasting glucose: 82 mg/dL
  • HbA1C: 5.2% (est avg 103 mg/dL)
  • TG/HDL Ratio: 1.4 (in mg/dl this < 2.0 - so insulin sensitive)

Thought I'd share where I am in my journey! If your feeling generous I'd love to see your metrics too!

Overall I feel great, I exercise 5x a week. I got sick once, and only after visiting a friend in the hospital and I caught their cough.

-3
Landman (en.wikipedia.org)
 

Excellent series, just finished season 1.

Great pacing and acting. Got into the social politics on the field, and added in some cartel spice.

Toward the end of season 1 there was a bunch of unnecessary relationship drama, but still great overall.

Billy Bob Thornton really sells this series.

 

Its a fascinating conversation, balancing the cultural sensitivities around diet and the power of ASF (animal sourced foods) in helping people with acute conditions.

Major focus on diabetes, and patients presenting to the ER with complications of metabolic syndrome.

  • 63% of ER patients are pure vegetarians
  • 33% eat meat/eggs/fish once a week or so

Dr. Ankur improved Tg/HDL ratio, GERD, acid reflux, bladder control, GI issues, fat loss, muscle soreness, and hypertension on a carnivore diet.

Trained in emergency medicine at George Washington University, Dr. Ankur is currently a Principal Consultant and Faculty of Emergency Medicine in New Delhi. He has a keen interest in trauma, airways, academic emergency medicine, resuscitation, point-of-care ultrasound (POCUS), and metabolic health. Dr. Ankur conceived and coined the term #SATisfied airway to promote awareness of innovative airway management techniques. With over 40 publications in national and international journals, he has delivered numerous talks at conferences worldwide. He is also the Creator-Founder of THE DESI EM PROJECT™, India’s first and only emergency medicine podcast, listened to in over 70 countries.

A self-taught nutrition advocate, Dr. Ankur focuses on raising awareness about species-specific carnivore lifestyles and addressing root causes of chronic non-communicable diseases. Recently, he has begun integrating emergency medicine with metabolic health research, spearheading studies in this emerging field.

Dr. Ankur serves as President of the Society for Emergency Medicine India (SEMI) – Delhi Chapter and chairs the Trauma Special Interest Group (SIG) for the International Federation for Emergency Medicine. He launched the #EACH1SAVE1™ campaign, empowering SEMI-Delhi members to teach bystander CPR in communities. Under his leadership, SEMI-Delhi organized India’s first carbon-neutral medical conferences, Best Practices in EM v1.0 and v2.0—the latter featuring the country’s inaugural all-women speaker lineup at a medical conference. He also contributes to the ACEP International Ambassador Regional Committee Leadership Team.

Timestamps:
00:00 Trailer and introduction
05:31 Nutrition’s impact on health awareness
06:34 Reevaluating statin use in normal lipid profiles
09:47 Enforcing sugar-free coffee policy
14:46 Diabetes and smoking concerns in India
16:49 Dietary factors in India's diabetes rates
20:18 Avoid frailty with nutrition & exercise
25:21 Calcium channel blockers in SVT management
29:03 Flawed incentives in healthcare system
30:58 Vegan vs. carnivore diet
34:42 Traditional vs. modern fat choices
39:19 Oats triggered TMJ issues
40:56 Perceptions of health and illness
46:09 India's massive cattle industry
47:27 Climate impact of monocropping
52:20 Vegetarian diet vs. medications
54:44 Where to find Ankur
 

DNS isn't resolving today for me, from multiple internet peering points.

 

Great film, lots of symbolism and a family story to boot

The Devil's Advocate (marketed as Devil's Advocate) is a 1997 American supernatural horror film directed by Taylor Hackford, written by Jonathan Lemkin and Tony Gilroy, and starring Keanu Reeves, Al Pacino and Charlize Theron. Based on Andrew Neiderman's 1990 novel, it is about a gifted young Florida lawyer invited to work for a major New York City law firm. As his wife becomes haunted by frightening visions, the lawyer slowly realizes that the firm's owner John Milton is the Devil.

 

Self insured company works with metabolic researchers to use TCF (total carbohydrate restriction / keto) and IF (intermittent fasting) to reduce their health care cost of chronic metabolic issues.

41 completed the one-year intervention. Mean weight loss for the 50 subjects in the intention-to-treat analysis was 19.5 ± 11.4 kg, corresponding to 15.5% total body weight loss with concomitant deprescription of 96 medications, while starting only 8 medications. In patients who discontinued GLP-1 receptor agonists, weight loss continued or was maintained. Annualized cost savings from the TOWARD approach were approximately -$1700 per patient, as compared to an annualized cost burden of roughly +$13000 per patient for a GLP-1 receptor agonist.

Full Paper https://doi.org/10.3389/fnut.2025.1548609

 

We have seen in many studies of carnivore populations (Inuit, native Americans, African) that they have near zero dental cavities.

It's pretty clear that cavities are related to PBFs/carbs/sugar.

https://www.youtube.com/watch?v=5zyvNYaUFq8 - great video going over the research, and our good friends observation and association

The whole debate around fluoride is a risk reward analysis, where the positive side is less cavities in children and the downsides are associative and hotly debated.

Seems the benefit that fluoride provides is only necessary because the standard diet promotes cavities, and a more human focused diet like carnivore is already protective and thus no need for fluoride.

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