I'm currently running on Debian Stable, but I was running on Debian Testing until Debian 12 released. RX 6700 XT + i5 11400f. I use debs for most things and Flatpak for everything that I can't find on repo.
I had no more or less issues on it than any other distro, I've never really had anything break but of course YMMV.
As a side note, I'd recommend trying Stable as well to see if it works well enough for you, then moving to testing if it doesn't. As long as the performance is fine enough for you, it's really nice having the system not really change since I only have to get a game working once, and it just keeps working exactly the same until the next Debian version with no surprises.