It it incredibly difficult to vet with 100% certainty that a binary you run it safe. If you have the source code, its so much easier. As others have said, the best way in piracy to be safe is downloading from a reputable source. Monkrus is pretty good. I am assuming you're referring to the Adobe master collection? If so, GenP is excellent (and open source).
If you are on windows, one thing you can do is run any programs in sandboxie and see what it writes to the disc. If it tries to edit things that it shouldn't like the registry or parts of the os that would be a red flag.
You could also setup firewall rules to block the application from accessing the internet. I am on macOS so I use a program called little snitch (lulu by objective see is also good). I am not familiar with the windows side of things. But essentially what I do is block the program and any processes it starts.
If you want to learn more about malware, https://objective-see.org/ is a great resource. It's macOS focused however but I've learned a ton from it. In particular their book on mac malware teaches a lot of analysis techniques.