I had it running on a Pi3 using the official homebridge image without any problems related to the Pi itself. Usually when there is a problem it’s because of a homebridge plugin or a config error.
I recommend assigning a fixed IP for the Pi‘s MAC address in your router.
You will also want to update Node.js regularly, which can be done with the hb-service CLI tool that comes preinstalled if you used the image. Therefore basic knowledge of using the console is required. If I remember correctly the console can be accessed in the Homebridge UI.