If you referring to GUIs:
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GTK for Python: https://www.gtk.org/docs/language-bindings/python/
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Qt for Python: https://www.qt.io/qt-for-python
If you mean making an executable that can run without separately installing a Python interpreter or PyPi dependencies, there are Python packagers like Pyinstaller: https://pyinstaller.readthedocs.io/en/stable/