this post was submitted on 01 Jul 2025
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https://en.m.wikipedia.org/wiki/MRNA_vaccine
The first (indirect) human mrna vaccine was trialed in 2001. A different direct infection trial was reported (completed and analyzed) in 2008 it was a safety and efficacy trial. Then there was the 2013 rabies trial (101 participants safety trial) then others for flu, zika, cmv, and chikungunya. This isn't a very complete list of the trials that occurred as many of the early ones were for cancers.
You can see a more complete but not necessarily full list of in progress and completed mrna trials https://clinicaltrials.gov/search?intr=Mrna easily noted is that between the rabies vaccine and the HIV (both before covid19 existed) there are already over 151 people that received it and both trials were safety trials. That's before the aforementioned cancer trials, your source is wrong. Unless it is for something rare safety trials are always done first or(more recently) in combination with the efficacy trial.