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Hot take: Strongest creatures in the setting shouldn't just be clowned by PCs with no resistance.
(ttrpg.network)
Inspired by frustrating conversation I had. For those curious, that was the statblock of Caine, father of the vampires.
This is very game dependent. Right now I'm in a pretty brutal one where everyone is branded by the goddess of mind control and we have miniboss encounters with our own former PCs who've been turned into grotesque monsters - but I've also played in games where the PCs were newcomers to Olympus and more or less ended up recreating the first few God of War games.